HYAJOINT Plus® is a synovial fluid supplement, also known as a viscosupplement, that replaces the hyaluronic acid naturally present in the joint. The treatment requires a single injection into the synovial cavity of the joint knee 3. HYAJOINT Plus® reduces knee pain and improves mobility for up to 6 months 1,2.
HYAJOINT Plus® is a safe and efficient viscosupplement that reduces pain and improves mobility in the osteoarthritic knee for up to 6 months with a single injection 1,2,3.
Sodium hyaluronate 60mg
One single injection per treatment for adult into the OA joint
3mL x 1 syringe
*This product is a class III medical device. CE marked (Notified body n°2797) in accordance with the rules and regulation in effect.
HYAJOINT Plus® is a non-animal sourced hyaluronic acid produced by microbial fermentation, thus eliminating potential risks associated with allergies to avian proteins 1.
*For more information, please consult the available patent.
Linear hyaluronic acid before cross-linking.
Cross-Linking technology with less BDDE, minimising the amount of BDDE residue.
Shown to be more efficient in pain relief than Synvisc-One® in a prospective, randomised double-blind, level I study 2.
The values of VAS score (mm) are given as the mean ± standard deviation. For statistical detail, please refer to the brochure.
Better improvement of pain relief by 33.3 mm on VAS score in patients treated with HYAJOINT Plus® compared to 23.4 mm in the Synvisc-One® group at 6 months (mean difference between groups -6.6; p=0.045).2
The frequencies and types of adverse events were comparable between Synvisc-One® and HYAJOINT Plus® groups. The majority of adverse events were mild or moderate, lasted 1 to 3 days, and resolved spontaneously or responded well to simple analgesics. The adverse events reported in each group were joint pain, joint swelling, joint stiffness, limb weakness, back pain. Twelve patients ( 9 treated with Synvisc-One® and 3 treated with HYAJOINT Plus®) developed joint effusion within 1 week after the injection, all infections revolved except for 2 patients treated with Synvisc-One® who required arthrocentesis for pain relief. No allergies, pseudosepsis or serious adverse events occurred during the study in either group.2
HYAJOINT Plus®, a long term treatment for symptomatic osteoarthritis; pain relief and restored mobility with a single injection 1.
6 months after injection of HYAJOINT Plus®, the WOMAC pain score (Western Ontario and McMaster Universities Osteoarthritis Index) was significantly reduced compared to the baseline (from 7.62 to 3.57; P<0.001)1
The mean VAS decreased by 28.45 mm from baseline at 6-month follow-up (from 60.12 to 31.67mm; p<0.001) 1.
The values of WOMAC pain score (points) are given as the mean ± standard deviation (7.62±0.49 and 3.57 ±0.40 at baseline and 6 months respectively) in 46 patients assessed using a Bonferroni post-hoc test. Adapted from Tuan et al, 2018.
The values of SLS duration (sec) are given as the mean ± standard deviation (14.95±2.97 and 26.37±3.83 at baseline and 6 months respectively) in 46 patients assessed using a Bonferroni post-hoc test. Adapted from Tuan et al, 2018.
The values of VAS score (mm) are given as the mean ± standard deviation (60.12±2.31 and 31.67±25.02 at baseline and 6 months respectively) in 46 patients assessed using repeated measures one-way ANOVA and a Bonferroni post-hoc test. Adapted from Tuan et al, 2018.
No infections, allergies or other serious adverse effects were reported. Five subjects developed joint pain without inflammatory signs and 1 patient developed mild and painful effusion which spontaneously subsided 9 days later.
1. Tuan S., Liou I., Su H., Tsai Y., Chen G. and Sun S._Improvement of self-reported functional scores and thickening of quadriceps and femoral intercondylar cartilage under ultrasonography after single intra-articular injection of a novel crosslinked hyaluronic acid in the treatment of the knee osteoarthritis. JBMR._2018 ; 31 : 709-718
2. Sun, S.-F., Hsu, C.-W., Lin, H.-S., Liou I.-H., Chen, Y.-H. and Hung C.-L._Comparison of Single Intra-Articular Injection ofNovel Hyaluronan (HYA-JOINT Plus) with Synvisc-One for Knee Osteoarthritis. JBJS._2017 ; 99(6) : 462-471
3. Instruction for use HYAJOINT Plus® (PIHPF-10(01) 20190801)
Macopharma exhibited to the 5th ISIAT congress from 3rd to 5th in Lisbon.
During this congress, Dr Raghu Raman, an eminent orthopaedic surgeon did a lecture on “Therapeutic Mechanisms and Clinical Potential of a Novel viscosupplement: What have we learned from molecular weight and cross-link rheology?”
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