Dispel knee pain and improve mobility with a single injection 1,2,3

HYAJOINT Plus® is a synovial fluid supplement, also known as a viscosupplement, that replaces the hyaluronic acid naturally present in the joint. The treatment requires a single injection into the synovial cavity of the joint knee 3. HYAJOINT Plus® reduces knee pain and improves mobility for up to 6 months 1,2.

HYAJOINT Plus® is a safe and efficient viscosupplement that reduces pain and improves mobility in the osteoarthritic knee for up to 6 months with a single injection 1,2,3.

Active Ingredient

Sodium hyaluronate 60mg

HA Concentration

60mg/3mL (2%)

Injection Regimen

One single injection per treatment for adult into the OA joint


3mL x 1 syringe

*This product is a class III medical device. CE marked (Notified body n°2797) in accordance with the rules and regulation in effect.

HYAJOINT Plus® is produced with a unique CHAPTM technology*

HYAJOINT Plus® is a non-animal sourced hyaluronic acid produced by microbial fermentation, thus eliminating potential risks associated with allergies to avian proteins 1.

HYAJOINT Plus® is synthesised by a novel cross-linking process using 1,4-butanediol diglycidyl ether (BDDE) to create an antidegradation feature. The patented CHAPTM (Cross-linked Hyaluronic Acid Platform) process prolongs the degradation time by carefully transforming linear hyaluronic acid to crosslinked hyaluronic acid and thus increasing the molecular weight (>15MDa). This cross-linking technology enables the creation of a viscous gel with increased density (2% HA, 20mg/ml)1,2. The carefully controlled cross-linked hyaluronic acid increases the viscoelastic properties of the synovial fluid reducing pain and restoring knee joint mobility 1,2.

*For more information, please consult the available patent.

Cross-linking Technology

Linear hyaluronic acid before cross-linking.

Cross-Linking technology with less BDDE, minimising the amount of BDDE residue.

HYAJOINT Plus® Clinical Efficacy

Shown to be more efficient in pain relief than Synvisc-One® in a prospective, randomised double-blind, level I study 2.

Study Design​

The values of VAS score (mm) are given as the mean ± standard deviation. For statistical detail, please refer to the brochure.


Better improvement of pain relief by 33.3 mm on VAS score in patients treated with HYAJOINT Plus® compared to 23.4 mm in the Synvisc-One® group at 6 months (mean difference between groups -6.6; p=0.045).2

Safety data

The frequencies and types of adverse events were comparable between Synvisc-One® and HYAJOINT Plus® groups. The majority of adverse events were mild or moderate, lasted 1 to 3 days, and resolved spontaneously or responded well to simple analgesics. The adverse events reported in each group were joint pain, joint swelling, joint stiffness, limb weakness, back pain. Twelve patients ( 9 treated with Synvisc-One® and 3 treated with HYAJOINT Plus®) developed joint effusion within 1 week after the injection, all infections revolved except for 2 patients treated with Synvisc-One® who required arthrocentesis for pain relief. No allergies, pseudosepsis or serious adverse events occurred during the study in either group.2

HYAJOINT Plus®, a long term treatment for symptomatic osteoarthritis; pain relief and restored mobility with a single injection 1.

Study Design​


6 months after injection of HYAJOINT Plus®, the WOMAC pain score (Western Ontario and McMaster Universities Osteoarthritis Index) was significantly reduced compared to the baseline (from 7.62 to 3.57; P<0.001)1

The Single Leg Stance (SLS) duration was significantly improved at 6 months after HYAJOINT Plus® injection compared to the baseline (from 14.95 to 26.37 sec; p=0.008) 1.

The mean VAS decreased by 28.45 mm from baseline at 6-month follow-up (from 60.12 to 31.67mm; p<0.001) 1.

The values of WOMAC pain score (points) are given as the mean ± standard deviation (7.62±0.49 and 3.57 ±0.40 at baseline and 6 months respectively) in 46 patients assessed using a Bonferroni post-hoc test. Adapted from Tuan et al, 2018.

The values of SLS duration (sec) are given as the mean ± standard deviation (14.95±2.97 and 26.37±3.83 at baseline and 6 months respectively) in 46 patients assessed using a Bonferroni post-hoc test. Adapted from Tuan et al, 2018.

The values of VAS score (mm) are given as the mean ± standard deviation (60.12±2.31 and 31.67±25.02 at baseline and 6 months respectively) in 46 patients assessed using repeated measures one-way ANOVA and a Bonferroni post-hoc test. Adapted from Tuan et al, 2018.

Safety data​

No infections, allergies or other serious adverse effects were reported. Five subjects developed joint pain without inflammatory signs and 1 patient developed mild and painful effusion which spontaneously subsided 9 days later.

Important safety information for HYAJOINT Plus®

HYAJOINT Plus®, should not be administered to patients who have experienced cases of past or present infections or skin diseases in the area of the injection site. Prior to injection, ask your patient if they have experienced hypersensitivity to any hyaluronic acid-based products. The injection of HYAJOINT Plus® must be administered by authorized personnel in accordance with local legislation.


1. Tuan S., Liou I., Su H., Tsai Y., Chen G. and Sun S._Improvement of self-reported functional scores and thickening of quadriceps and femoral intercondylar cartilage under ultrasonography after single intra-articular injection of a novel crosslinked hyaluronic acid in the treatment of the knee osteoarthritis. JBMR._2018 ; 31 : 709-718

2. Sun, S.-F., Hsu, C.-W., Lin, H.-S., Liou I.-H., Chen, Y.-H. and Hung C.-L._Comparison of Single Intra-Articular Injection ofNovel Hyaluronan (HYA-JOINT Plus) with Synvisc-One for Knee Osteoarthritis. JBJS._2017 ; 99(6) : 462-471

3. Instruction for use HYAJOINT Plus® (PIHPF-10(01) 20190801)


Lire la vidéo

Macopharma exhibited to the 5th ISIAT congress from 3rd to 5th in Lisbon.

During this congress, Dr Raghu Raman, an eminent orthopaedic surgeon did a lecture on “Therapeutic Mechanisms and Clinical Potential of a Novel viscosupplement: What have we learned from molecular weight and cross-link rheology?”

Contact us

For more information please fill out the Contact Form below
and we will respond to you shortly

Shopping Basket


Healthcare professional confirmation

The information on the page you are about to enter is intended for Healthcare professionals only. By clicking the box below you confirm that you are a healthcare professional.